References
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2017, Suzhou (China): Continuous Manufacturing
Project Management An innovative continuous reaction process was developed by the R&D department of our client to replace an existing batch process. Due to the special requirements (long residence times, narrow RT distribution, compact construction, easy cleanability, etc.) sterile shell-and-tube heat exchangers were selected. The quasi-dead-zone-free design allowed to minimize back-mixing and therefore improve the reaction yield. Consolution AG developed the conceptual and basic design, coordinated the purchase of main equipment and supported the local team "on-site" during detail design. |
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2016, Basel (Switzerland): Product Launch
Process Engineering Consolution AG supported the project team with two project engineers during planning, construction and commissioning of the modification of an existing pharmaceutical plant to produce a new drug. The scope included: conceptual, basic und detail design, support during purchase of equipment and construction, commissioning (DQ/IQ/OQ) and start-up. |
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2015, Basel (Switzerland): DCS Migration
Commissioning of new automation system Consolution AG supported the project team with two project engineers during the operational qualification of the replacement of the automation system (from PCS7 to DeltaV) in an existing plant for the production of a drug to combat high blood pressure. |
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2013/2014, Basel (Switzerland): Product Transfer
Process Engineering Consolution AG supported the project team with two project engineers and a CAD-technician during planning, construction and commissioning of the modification of an existing pharmaceutical plant to produce a new drug. The scope included: conceptual, basic und detail design, purchase of equipment (incl. FAT/SAT), commissioning (DQ/IQ/OQ) and start-up. |
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2012, Basel (Switzerland): Small Scale Production Highly Actives
Project Initiation API production plant Market evaluation and Conceptual Design of material handling and production plant for elaboration of highly active substances. All production areas were designed under containment for substances hazard class 3B. |
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2012, Marburg (Germany): Vaccines production
Re-Design production plant Project Management for preparation of the transfer of an existing production plant of vaccines-adjuvants to a new production building. |
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2012-2014, Singapore: Biotech production
Diaphragm valves catalog Consolution AG supported the project team during the elaboration of the instrument catalogue of diaphragm valves (app. 6000 valve bodies / 8000 actuators). The tasks included: - Technical support - Coordination of project team and suppliers - Elaboration of the instrument catalogue - Implementation in the integrated Engineering Platform (iEP) under Comos linking the real-world devices. |
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2011, Basel (Switzerland): Brine cooling plant
Brine cooling plant -30/-24°C (3x700 kW) Consolution AG supported the project team during planning and construction of the new brine conditioning plant in the following points: - Layout - Coordination during planning - Construction documentation - Project and plant documentation |
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2012, Basel (Switzerland): Container washing plant
Design, installation and commissioning. Consolution AG supported with a project engineer and a CAD-technician the expansion of the cleaning plant for containers. The plant, designed for drums and small bins required for the handling of API, must guarantee GMP compliance. |
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2011, Basel (Switzerland): Discharge plant
Design, installation and commissioning Consolution AG supported the project team with two project engineers and a CAD-technician during planning and construction of a discharge station for liquid, highly active and chemical residues. The tanks required for the transport of the liquid residues can now be connected in a safe manner. |
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2011, Grimsby (UK): Continuous Manufacturing
Project Management Consolution AG developed the basic design and coordinated the detail design (on site) of an innovative continuous reaction process developed to replace the existing batch process. |
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2008, Basel (Switzerland): Large-scale project for drug production plant
Process Engineering Consolution AG supported the project team with three project engineers during qualification and start-up of a plant for production of a drug to combat high blood pressure. |
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2008, Kaiseraugst (Switzerland): 3D-Planung
Process Engineering Consolution AG supported the client during the 2D/3D design of a production plant for manufacturing of a pharmaceutical active ingredient. |
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2008, Grimsby (UK): Capacity increase of production plant
Mechanical Engineering (Equipment Technology) Technical support during purchase of equipment: - Pressure nutsche filter 4m2/316L - Hydrogenation reactor 10m3/316L - Heat exchangers, pumps, etc. |
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2007, Basel (Switzerland): Cooling water plant
Cooling water conditioning (2x2.8MW) Consolution AG supported the project team with: - Feasibility analysis and layout - PFD and P&ID - Coordination during planning and construction - Project and plant documentation. |
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2004-2007, Basel (Switzerland): Small Scale Production Plant
Process Engineering Consolution AG supported the project team with a process engineer responsible for a whole production step during planning, construction and commissioning of a multipurpose plant for manufacturing of APIs. The scope included: conceptual, basic und detail design, purchase of equipment (incl. FAT/SAT), commissioning (DQ/IQ/OQ) and start-up. |
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2006, Grimsby (UK): Capacity increase for drug production
Coordination Mechanical Engineering Coordination Engineering Contractors "Mechanical Engineering" (15'000 MH): - Documentation of technical requirements - Technical support during "auditing" of suppliers. - Technical support during purchase of equipment. - Technical support during manufacturing (expediting) - Commissioning of equipment (FAT) - Document handling und creation of final documentation. |
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2006 - 2014, Basel (Switzerland): Modular Technology
Long-term Agreement Modular Technology Consolution AG supported the creation of an equipment module library during the planning of several API production plants. The equipment modules were developed to cover different degrees of automation levels and were also implemented in the “integrated Engineering Platform” of the client, to be available for projects worldwide. |
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2003, Grimsby (UK): Large-scale project for drug production plant
Mechanical Engineering (Equipment Technology) Technical support during purchase of equipment: - Documentation of technical requirements - Technical support during purchase of Equipment - Technical support during manufacturing (Expediting) - Commissioning of equipment (FAT) - Document handling und creation of final documentation. |
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2002, Huningue (France): Biotech production
Process Engineering (Basic Engineering) Consolution AG supported the project team with two qualified engineers. Main tasks: - Planning and construction of the CIP/SIP (Cleaning in Place / Sterilisation in Place) plant and loops, as well as Loops for Purified Water and Water for Injection. - Creation of the respective P&IDs and process description (in German, English and French). - Plant and equipment design. - Adherence to GMP requirements. - Startup of the CIP/SIP plant. - Validation of the purified water supply. |
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2001, Basel (Switzerland) / Ringaskiddy (Ireland): Chemical API-production
Process Engineering (Basic Design) Consolution AG supported the project team with one qualified engineer responsible as Module Owner for falling film evaporators, Extractors und buffer tanks for a project in the area of Pharma. Main tasks: - Creation of the P&IDs. - Creation of the process description (in German, and English). - Plant and equipment design. - Adherence to GMP requirements. |
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Since 1998, Basel (Switzerland): CAE-IT/CAD-Support
CAE-IT/ Global Pharma Engineering The previous CAE-Environments (Bentley and Intergraph-PDS) needed to be integrated into the "integrated Engineering Platform" (iEP) under Comos. Consolution AG supported the implementation of the iEP (including data migration from the old systems into COMOS) with one engineer. |
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Since 1998, Kaiseraugst (Switzerland): System & Data management
System support to plant owner of vitamin production. Consolution AG supports with one CAE-technician the areas of 2D und 3D Design, as well as the related data management. |